NAAD sodium salt

Research use only, not for human use.

NAAD sodium salt is a substrate of nicotinamide adenine dinucleotide synthase and can be used in studies about the specificity and kinetics of the substrate.

NAAD sodium salt is a substrate of nicotinamide adenine dinucleotide synthase and can be used in studies about the specificity and kinetics of the substrate.(In Vitro):NAAD sodium salt, produced in the biosynthesis of NAD+ from tryptophan and NA2, was elevated from less than 20?nM to as high as 0.91?μM in peripheral blood mononuclear cells.(In Vivo):In mice, after the administration of nicotinic acid (500?mg/kg; i.p.), NAAD sodium salt is observed in kidneys, ovaries, lung, heart, and brain while after the administration of radioactive nicotinamide (500?mg/kg; i.p.), NAAD sodium salt is only in mouse liver.

In peripheral blood mononuclear cells (PBMC), NAAD sodium is only expected to be produced in biosynthesis of NAD+ from tryptophan and NA2, was elevated from less than 20?nM to as high as 0.91?μM.Nicotinamide adenine dinucleotide synthetases (NADS) catalyze the amidation of nicotinic acid adenine dinucleotide (NAAD) to yield the enzyme cofactor nicotinamide adenine dinucleotide (NAD).

In mice, when nicotinic acid (NA) is provided by oral gavage, liver NA peaked (340?pmol/mg) in 15?min. Hepatic NA appearance is followed by an expected peak of 220 NAAD sodium at 1?h post gavage and a rise in hepatic NAD+ from 990 baseline to 2200 at 2?h.NAAD sodium is reported in mouse liver when 500?mg/kg of radioactive nicotinamide (Nam) is injected intraperitoneally (IP) into the body cavity of mice. However, NAAD sodium is observed in kidneys, ovaries, lung, heart and brain in addition to liver in mice IP-injected with 500?mg/kg of NA but not Nam.

NAAD Na salt | NAAD Na, NaAD | Deamido Nad Sodium Salt

Others

Other Targets

AUTACs

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104809-30-5

686.395

C21H25N6NaO15P2

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (145.69 mM)

[Na+].Nc1ncnc2n(cnc12)C1OC(COP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)[n+]2cccc(c2)C(O)=O)C(O)C1O

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(-20℃)

With Ice Pack

≥ 2 years